Assay Detail
Binding
CHEMBL3102463
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Inhibition of human HDAC6 using RHKK(Ac) as substrate by fluorimetric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.06 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098602 | — | — | 1 | 8.70 |
| CHEMBL3098604 | — | — | 1 | 8.52 |
| CHEMBL3098695 | — | — | 1 | 8.52 |
| CHEMBL3098693 | — | — | 1 | 8.40 |
| CHEMBL3098606 | — | — | 1 | 8.40 |
| CHEMBL3098694 | — | — | 1 | 8.40 |
| CHEMBL3098689 | — | — | 1 | 8.30 |
| CHEMBL3098688 | — | — | 1 | 8.22 |
| CHEMBL1089495 | — | — | 1 | 8.22 |
| CHEMBL3098691 | — | — | 1 | 8.22 |
| CHEMBL3098690 | — | — | 1 | 8.10 |
| CHEMBL3098687 | — | — | 1 | 8.10 |
| CHEMBL3098605 | — | — | 1 | 7.92 |
| CHEMBL3098692 | — | — | 1 | 7.72 |
| CHEMBL3098603 | — | — | 1 | 7.66 |
| CHEMBL483477 | — | — | 1 | 7.60 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.54 |
| CHEMBL3098697 | — | — | 1 | 7.51 |
| CHEMBL3098696 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098602 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3098604 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3098695 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3098693 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3098606 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3098694 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3098689 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3098688 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1089495 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3098691 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3098690 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3098687 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3098605 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3098692 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3098603 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL483477 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3098697 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3098696 | — | IC50 | = | 75.0 | nM | 7.12 |