Assay Detail
Functional
CHEMBL3106641
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production administered 1 hr prior to LPS-challenge measured after 24 hrs by EIA
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.04 | 8.40 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3103243 | — | — | 1 | 8.40 |
| CHEMBL3103247 | — | — | 1 | 8.22 |
| CHEMBL3103240 | — | — | 1 | 8.19 |
| CHEMBL3103246 | — | — | 1 | 8.17 |
| CHEMBL7162 | NS-398 | — | 1 | 8.15 |
| CHEMBL286738 | IROSUSTAT | 2.0 | 2 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3103243 | — | IC50 | = | 4.02 | nM | 8.40 |
| CHEMBL3103247 | — | IC50 | = | 6.04 | nM | 8.22 |
| CHEMBL3103240 | — | IC50 | = | 6.45 | nM | 8.19 |
| CHEMBL3103246 | — | IC50 | = | 6.75 | nM | 8.17 |
| CHEMBL7162 | NS-398 | IC50 | = | 7.01 | nM | 8.15 |
| CHEMBL286738 | IROSUSTAT | IC50 | = | 81.04 | nM | 7.09 |
| CHEMBL286738 | IROSUSTAT | Inhibition | - | % | - |