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Assay Detail

CHEMBL3106643

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages.
Jang HL, El-Gamal MI, Choi HE, Choi HY, Lee KT, Oh CH.
Bioorg Med Chem Lett (2014) 24 : 571 -575
PubMed 24360561 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.66 5.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3103243 1 5.04
CHEMBL3103244 1 4.98
CHEMBL3103237 1 4.69
CHEMBL3103242 1 4.67
CHEMBL3103235 1 4.63
CHEMBL3103236 1 4.62
CHEMBL3103241 1 4.61
CHEMBL3103234 1 4.04
CHEMBL3103247 1 -
CHEMBL3103246 1 -
CHEMBL3103245 1 -
CHEMBL3103240 1 -
CHEMBL3103239 1 -
CHEMBL3103238 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3103243 IC50 = 9200.0 nM 5.04
CHEMBL3103244 IC50 = 10500.0 nM 4.98
CHEMBL3103237 IC50 = 20300.0 nM 4.69
CHEMBL3103242 IC50 = 21500.0 nM 4.67
CHEMBL3103235 IC50 = 23400.0 nM 4.63
CHEMBL3103236 IC50 = 23900.0 nM 4.62
CHEMBL3103241 IC50 = 24500.0 nM 4.61
CHEMBL3103234 IC50 = 90800.0 nM 4.04
CHEMBL3103247 IC50 > 100000.0 nM -
CHEMBL3103246 IC50 > 100000.0 nM -
CHEMBL3103245 IC50 > 100000.0 nM -
CHEMBL3103240 IC50 > 100000.0 nM -
CHEMBL3103239 IC50 > 100000.0 nM -
CHEMBL3103238 IC50 > 100000.0 nM -