Assay Detail
Binding
CHEMBL3106798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis Dxr
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL5630) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.98 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 6.36 |
| CHEMBL3103256 | — | — | 1 | 5.97 |
| CHEMBL205338 | FR-900098 | — | 1 | 5.62 |
| CHEMBL3103258 | — | — | 1 | - |
| CHEMBL3103257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3103256 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL205338 | FR-900098 | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL3103258 | — | IC50 | - | — | - | |
| CHEMBL3103257 | — | IC50 | - | — | - |