Assay Detail
Binding
CHEMBL3107209
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Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Glycine max |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.39 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243677 | — | — | 1 | 4.75 |
| CHEMBL457821 | — | — | 1 | 4.02 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243677 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL457821 | — | Ki | = | 95400.0 | nM | 4.02 |
| CHEMBL50 | QUERCETIN | Ki | = | 106700.0 | nM | - |
| CHEMBL151 | LUTEOLIN | Ki | = | 121700.0 | nM | - |