Assay Detail
Functional
CHEMBL3107214
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Intrinsic activity at human melatonin MT2 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 1 hr
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New melatonin (MT1/MT2) ligands: design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 8.94 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3103593 | — | — | 1 | 10.15 |
| CHEMBL3103597 | — | — | 1 | 10.10 |
| CHEMBL3103583 | — | — | 1 | 10.00 |
| CHEMBL138321 | — | — | 1 | 9.72 |
| CHEMBL3103595 | — | — | 1 | 9.70 |
| CHEMBL3103598 | — | — | 1 | 9.68 |
| CHEMBL3103594 | — | — | 1 | 9.68 |
| CHEMBL3103596 | — | — | 1 | 9.52 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.40 |
| CHEMBL323332 | — | — | 1 | 9.15 |
| CHEMBL3103585 | — | — | 1 | 8.82 |
| CHEMBL3103586 | — | — | 1 | 7.85 |
| CHEMBL3103575 | — | — | 1 | 7.80 |
| CHEMBL3103590 | — | — | 1 | 7.42 |
| CHEMBL3103584 | — | — | 1 | 7.29 |
| CHEMBL3103580 | — | — | 1 | 6.83 |
| CHEMBL3103587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3103593 | — | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL3103597 | — | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL3103583 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL138321 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3103595 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3103598 | — | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3103594 | — | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3103596 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL45 | MELATONIN | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL323332 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3103585 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3103586 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3103575 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3103590 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3103584 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3103580 | — | EC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3103587 | — | EC50 | > | 10000.0 | nM | - |