Assay Detail
Functional
CHEMBL3107266
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Antiplatelet activity against New Zealand white rabbit platelets assessed as inhibition of PAF-induced platelet aggregation preincubated for 2 mins before challenge measured after 2 mins by spectrophotometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lignans from the aerial parts of Saururus chinensis: isolation, structural characterization, and their effects on platelet aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.45 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104952 | — | — | 1 | 5.04 |
| CHEMBL3104950 | — | — | 1 | 4.43 |
| CHEMBL3104948 | — | — | 1 | 4.21 |
| CHEMBL3104953 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104952 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3104950 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL3104948 | — | IC50 | = | 61700.0 | nM | 4.21 |
| CHEMBL3104953 | — | IC50 | = | 79400.0 | nM | 4.10 |