Assay Detail
Binding
CHEMBL3107404
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Inhibition of COX-1 in human whole blood assessed as thromboxane B2 production by RIA
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.61 | 6.22 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104556 | — | — | 2 | 6.22 |
| CHEMBL3104539 | — | — | 1 | 5.72 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.90 |
| CHEMBL3104549 | — | — | 2 | - |
| CHEMBL3104551 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104556 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3104539 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL118 | CELECOXIB | IC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL3104549 | — | Inhibition | - | % | - | |
| CHEMBL3104551 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL3104549 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL3104556 | — | Inhibition | - | % | - |