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Assay Detail

CHEMBL3107427

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human RCC4 cells after 4 days by XTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type RCC4
Confidence 1 — Organism
Curated By Autocuration

Publication

Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents.
Bonnet M, Flanagan JU, Chan DA, Giaccia AJ, Hay MP.
Bioorg Med Chem (2014) 22 : 711 -720
PubMed 24387866 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.69 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3105156 1 6.80
CHEMBL3105157 1 5.77
CHEMBL565269 1 5.68
CHEMBL3105160 1 5.54
CHEMBL3105162 1 5.24
CHEMBL3105163 1 5.10
CHEMBL3105164 1 -
CHEMBL3105161 1 -
CHEMBL3105159 1 -
CHEMBL3105158 1 -
CHEMBL3105170 1 -
CHEMBL3105169 1 -
CHEMBL3105168 1 -
CHEMBL3105167 1 -
CHEMBL3105166 1 -
CHEMBL3105165 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3105156 IC50 = 160.0 nM 6.80
CHEMBL3105157 IC50 = 1700.0 nM 5.77
CHEMBL565269 IC50 = 2100.0 nM 5.68
CHEMBL3105160 IC50 = 2900.0 nM 5.54
CHEMBL3105162 IC50 = 5800.0 nM 5.24
CHEMBL3105163 IC50 = 7900.0 nM 5.10
CHEMBL3105164 IC50 > 40000.0 nM -
CHEMBL3105161 IC50 > 40000.0 nM -
CHEMBL3105159 IC50 > 40000.0 nM -
CHEMBL3105158 IC50 > 40000.0 nM -
CHEMBL3105170 IC50 < 1000.0 nM -
CHEMBL3105169 IC50 < 1000.0 nM -
CHEMBL3105168 IC50 < 1000.0 nM -
CHEMBL3105167 IC50 < 1000.0 nM -
CHEMBL3105166 IC50 < 1000.0 nM -
CHEMBL3105165 IC50 < 1000.0 nM -