Assay Detail
Binding
CHEMBL3107541
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Inhibition of LPS-induced COX-2 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of prostaglandin E2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by RIA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.79 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104559 | — | — | 1 | 7.35 |
| CHEMBL3104552 | — | — | 1 | 7.33 |
| CHEMBL3104549 | — | — | 1 | 7.27 |
| CHEMBL3104545 | — | — | 1 | 7.17 |
| CHEMBL3104540 | — | — | 1 | 7.17 |
| CHEMBL3104548 | — | — | 1 | 7.07 |
| CHEMBL3104550 | — | — | 1 | 6.85 |
| CHEMBL3104541 | — | — | 1 | 6.85 |
| CHEMBL3104547 | — | — | 1 | 6.80 |
| CHEMBL3104555 | — | — | 1 | 6.60 |
| CHEMBL3104556 | — | — | 1 | 6.60 |
| CHEMBL3104558 | — | — | 1 | 6.54 |
| CHEMBL3104554 | — | — | 1 | 6.52 |
| CHEMBL3104539 | — | — | 1 | 6.52 |
| CHEMBL3104543 | — | — | 1 | 6.51 |
| CHEMBL3104557 | — | — | 1 | 6.51 |
| CHEMBL3104544 | — | — | 1 | 5.80 |
| CHEMBL3104542 | — | — | 1 | - |
| CHEMBL3104546 | — | — | 1 | - |
| CHEMBL3104551 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104559 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3104552 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3104549 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3104545 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3104540 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3104548 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3104550 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3104541 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3104547 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3104555 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3104556 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL3104558 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3104554 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3104539 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3104543 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3104557 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3104544 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3104542 | — | IC50 | - | — | - | |
| CHEMBL3104546 | — | IC50 | - | — | - | |
| CHEMBL3104551 | — | IC50 | > | 10000.0 | nM | - |