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Assay Detail

CHEMBL3107753

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
Keenan M, Chaplin JH, Alexander PW, Abbott MJ, Best WM, Khong A, Botero A, Perez C, Cornwall S, Thompson RA, White KL, Shackleford DM, Koltun M, Chiu FC, Morizzi J, Ryan E, Campbell M, von Geldern TW, Scandale I, Chatelain E, Charman SA.
J Med Chem (2013) 56 : 10158 -10170
PubMed 24304150 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 4.31 4.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104531 1 4.70
CHEMBL3104376 1 4.68
CHEMBL3104477 1 4.55
CHEMBL3104533 1 4.50
CHEMBL3104526 1 4.42
CHEMBL3104537 1 4.40
CHEMBL3104525 1 4.33
CHEMBL3104528 1 4.29
CHEMBL3104475 1 4.29
CHEMBL3104484 1 4.28
CHEMBL3104534 1 4.27
CHEMBL1863286 1 4.27
CHEMBL3104529 1 4.26
CHEMBL3104474 1 4.26
CHEMBL3104473 1 4.24
CHEMBL3104485 1 4.24
CHEMBL3104479 1 4.24
CHEMBL3104530 1 4.24
CHEMBL3104375 1 4.22
CHEMBL3104486 1 4.21
CHEMBL3104535 1 4.21
CHEMBL3104527 1 4.19
CHEMBL3104488 1 4.19
CHEMBL3104532 1 4.19
CHEMBL3104489 1 4.16
CHEMBL3104472 1 4.15
CHEMBL1863275 1 -
CHEMBL3104374 1 -
CHEMBL1863145 1 -
CHEMBL3104536 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104531 IC50 = 20000.0 nM 4.70
CHEMBL3104376 IC50 = 21000.0 nM 4.68
CHEMBL3104477 IC50 = 28000.0 nM 4.55
CHEMBL3104533 IC50 = 32000.0 nM 4.50
CHEMBL3104526 IC50 = 38000.0 nM 4.42
CHEMBL3104537 IC50 = 40000.0 nM 4.40
CHEMBL3104525 IC50 = 47000.0 nM 4.33
CHEMBL3104528 IC50 = 51000.0 nM 4.29
CHEMBL3104475 IC50 = 51000.0 nM 4.29
CHEMBL3104484 IC50 = 52000.0 nM 4.28
CHEMBL1863286 IC50 = 54000.0 nM 4.27
CHEMBL3104534 IC50 = 54000.0 nM 4.27
CHEMBL3104529 IC50 = 55000.0 nM 4.26
CHEMBL3104474 IC50 = 55000.0 nM 4.26
CHEMBL3104530 IC50 = 58000.0 nM 4.24
CHEMBL3104473 IC50 = 57000.0 nM 4.24
CHEMBL3104479 IC50 = 57000.0 nM 4.24
CHEMBL3104485 IC50 = 58000.0 nM 4.24
CHEMBL3104375 IC50 = 60000.0 nM 4.22
CHEMBL3104486 IC50 = 61000.0 nM 4.21
CHEMBL3104535 IC50 = 61000.0 nM 4.21
CHEMBL3104527 IC50 = 64000.0 nM 4.19
CHEMBL3104488 IC50 = 65000.0 nM 4.19
CHEMBL3104532 IC50 = 64000.0 nM 4.19
CHEMBL3104489 IC50 = 69000.0 nM 4.16
CHEMBL3104472 IC50 = 71000.0 nM 4.15
CHEMBL3104490 IC50 > 100000.0 nM -
CHEMBL3104487 IC50 > 100000.0 nM -
CHEMBL3104483 IC50 > 100000.0 nM -
CHEMBL3104482 IC50 > 100000.0 nM -
CHEMBL3104481 IC50 > 100000.0 nM -
CHEMBL3104480 IC50 > 100000.0 nM -
CHEMBL3104478 IC50 > 100000.0 nM -
CHEMBL3104476 IC50 > 100000.0 nM -
CHEMBL3104538 IC50 > 100000.0 nM -
CHEMBL3104536 IC50 > 100000.0 nM -
CHEMBL1863145 IC50 > 100000.0 nM -
CHEMBL3104374 IC50 > 100000.0 nM -
CHEMBL1863275 IC50 > 100000.0 nM -