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Assay Detail

CHEMBL3108108

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Binding
Inhibition of influenza A virus RNA-dependent RNA polymerase subunit PA endonuclease activity
ChEMBL ↗
43
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking.
Yan Z, Zhang L, Fu H, Wang Z, Lin J.
Bioorg Med Chem Lett (2014) 24 : 539 -547
PubMed 24365156 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 5.12 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2040640 — — 1 6.72
CHEMBL2040554 — — 1 6.48
CHEMBL463590 — — 2 6.37
CHEMBL2040586 — — 1 6.27
CHEMBL2040602 — — 1 6.10
CHEMBL16632 — — 1 6.05
CHEMBL2040587 — — 1 5.96
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 2 5.72
CHEMBL2040605 — — 1 5.55
CHEMBL2040606 — — 1 5.46
CHEMBL1829211 — — 1 5.43
CHEMBL2040601 — — 1 5.32
CHEMBL16320 — — 1 5.26
CHEMBL2040608 — — 1 5.19
CHEMBL3103964 — — 1 5.10
CHEMBL3103972 — — 1 5.10
CHEMBL16377 — — 1 5.05
CHEMBL3103975 — — 1 5.02
CHEMBL3103968 — — 1 5.02
CHEMBL3103981 — — 1 5.00
CHEMBL3103971 — — 1 5.00
CHEMBL3103973 — — 1 5.00
CHEMBL3103974 — — 1 4.96
CHEMBL429766 — — 1 4.85
CHEMBL3103967 — — 1 4.77
CHEMBL3103979 — — 1 4.75
CHEMBL3103976 — — 1 4.70
CHEMBL467389 — — 1 4.67
CHEMBL3103966 — — 1 4.59
CHEMBL16299 — — 1 4.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2040640 — IC50 = 190.55 nM 6.72
CHEMBL2040554 — IC50 = 331.13 nM 6.48
CHEMBL463590 — IC50 = 430.0 nM 6.37
CHEMBL463590 — IC50 = 426.58 nM 6.37
CHEMBL2040586 — IC50 = 537.03 nM 6.27
CHEMBL2040602 — IC50 = 794.33 nM 6.10
CHEMBL16632 — IC50 = 891.25 nM 6.05
CHEMBL2040587 — IC50 = 1096.48 nM 5.96
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 1900.0 nM 5.72
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 1995.26 nM 5.70
CHEMBL2040605 — IC50 = 2818.38 nM 5.55
CHEMBL2040606 — IC50 = 3467.37 nM 5.46
CHEMBL1829211 — IC50 = 3715.35 nM 5.43
CHEMBL2040601 — IC50 = 4786.3 nM 5.32
CHEMBL16320 — IC50 = 5495.41 nM 5.26
CHEMBL2040608 — IC50 = 6456.54 nM 5.19
CHEMBL3103972 — IC50 = 7943.28 nM 5.10
CHEMBL3103964 — IC50 = 7943.28 nM 5.10
CHEMBL16377 — IC50 = 8912.51 nM 5.05
CHEMBL3103968 — IC50 = 9549.93 nM 5.02
CHEMBL3103975 — IC50 = 9549.93 nM 5.02
CHEMBL3103981 — IC50 = 10000.0 nM 5.00
CHEMBL3103973 — IC50 = 10000.0 nM 5.00
CHEMBL3103971 — IC50 = 10000.0 nM 5.00
CHEMBL3103974 — IC50 = 10964.78 nM 4.96
CHEMBL429766 — IC50 = 14125.38 nM 4.85
CHEMBL3103967 — IC50 = 16982.44 nM 4.77
CHEMBL3103979 — IC50 = 17782.79 nM 4.75
CHEMBL3103976 — IC50 = 19952.62 nM 4.70
CHEMBL467389 — IC50 = 21379.62 nM 4.67
CHEMBL3103966 — IC50 = 25703.96 nM 4.59
CHEMBL16299 — IC50 = 28840.32 nM 4.54
CHEMBL3103969 — IC50 = 32359.37 nM 4.49
CHEMBL3103980 — IC50 = 34673.69 nM 4.46
CHEMBL1911316 — IC50 = 36307.81 nM 4.44
CHEMBL3103977 — IC50 = 38018.94 nM 4.42
CHEMBL276589 — IC50 = 38018.94 nM 4.42
CHEMBL3103970 — IC50 = 39810.72 nM 4.40
CHEMBL3103965 — IC50 = 39810.72 nM 4.40
CHEMBL430143 — IC50 = 44668.36 nM 4.35
CHEMBL3103978 — IC50 = 47863.01 nM 4.32
CHEMBL16665 — IC50 = 50118.72 nM 4.30
CHEMBL277284 — IC50 = 50118.72 nM 4.30