Compound Detail
CHEMBL16320
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Basic Information
| ChEMBL ID | CHEMBL16320 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SIXHCCPAJIVTOY-UITAMQMPSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
238.3
MW (Da)
1.77
ALogP
4
HBA
1
HBD
70.0
PSA (Ų)
0.46
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 5.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polymerase acidic protein CHEMBL1169598 | IC50 | 5.29 | 5.275 | 5100.0 | 4 |
| Unchecked CHEMBL612545 | IC50 | 5.26 | 5.26 | 5495.4 | 1 |
| unidentified influenza virus CHEMBL613128 | IC50 | 5.26 | 5.26 | 5500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polymerase acidic protein | IC50 | = | 5100.0 | nM | 5.29 | Inhibition of cap 1 ALMV primed Influenza transcriptase | 11485475 |
| Polymerase acidic protein | IC50 | = | 5100.0 | nM | 5.29 | Inhibition of influenza A virus (A/PR/8/34) N-terminal PA endonuclease using 880... | 28118010 |
| Polymerase acidic protein | IC50 | = | 5500.0 | nM | 5.26 | Inhibitory concentration against cap-dependent endonuclease activity of influenz... | 12646026 |
| unidentified influenza virus | IC50 | = | 5500.0 | nM | 5.26 | Antiviral activity against influenza virus | 19112024 |
| Unchecked | IC50 | = | 5495.41 | nM | 5.26 | Inhibition of influenza A virus RNA-dependent RNA polymerase subunit PA endonucl... | 24365156 |
| Polymerase acidic protein | IC50 | = | 5500.0 | nM | 5.26 | Inhibition of Influenza A/PR/8/34 virus PA endonuclease by cap dependent RNA pol... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12646026 | 10.1021/jm020334u | Polymerase acidic protein | 1 |
| 19112024 | 10.1016/j.bmc.2008.11.075 | unidentified influenza virus | 1 |
| 11485475 | 10.1021/jo015665d | Polymerase acidic protein | 1 |
| 24365156 | 10.1016/j.bmcl.2013.12.026 | Unchecked | 1 |
| - | 10.1039/C5MD00439J | Polymerase acidic protein | 1 |
| 28118010 | 10.1021/acs.jmedchem.6b01227 | Polymerase acidic protein | 1 |
Data from ChEMBL 36 via Core Engine