Assay Detail
Binding
CHEMBL4008215
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Inhibition of influenza A virus (A/PR/8/34) N-terminal PA endonuclease using 880 nucleotide ALMV cap1 primer RNA as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polymerase acidic protein (CHEMBL1169598) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.69 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2040602 | — | — | 1 | 6.10 |
| CHEMBL16632 | — | — | 1 | 6.05 |
| CHEMBL2040605 | — | — | 1 | 5.55 |
| CHEMBL2040606 | — | — | 1 | 5.46 |
| CHEMBL16320 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2040602 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL16632 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2040605 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2040606 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL16320 | — | IC50 | = | 5100.0 | nM | 5.29 |