Assay Detail
Functional
CHEMBL763331
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Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | unidentified influenza virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polymerase acidic protein (CHEMBL1169598) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.00 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278402 | — | — | 1 | 6.37 |
| CHEMBL16632 | — | — | 1 | 6.05 |
| CHEMBL16405 | — | — | 1 | 5.30 |
| CHEMBL16320 | — | — | 1 | 5.26 |
| CHEMBL16755 | — | — | 1 | 4.82 |
| CHEMBL16326 | — | — | 1 | 4.67 |
| CHEMBL2040641 | — | — | 1 | 4.53 |
| CHEMBL16384 | — | — | 1 | 4.02 |
| CHEMBL16419 | — | — | 1 | 4.00 |
| CHEMBL275148 | — | — | 1 | - |
| CHEMBL16281 | — | — | 1 | - |
| CHEMBL16633 | — | — | 1 | - |
| CHEMBL16365 | — | — | 1 | - |
| CHEMBL16300 | BENZOHYDROXAMATE | — | 1 | - |
| CHEMBL461059 | — | — | 1 | - |
| CHEMBL277090 | — | — | 1 | - |
| CHEMBL16444 | — | — | 1 | - |
| CHEMBL276057 | — | — | 1 | - |
| CHEMBL16393 | — | — | 1 | - |
| CHEMBL16513 | — | — | 1 | - |
| CHEMBL277286 | — | — | 1 | - |
| CHEMBL16295 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278402 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL16632 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL16405 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL16320 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL16755 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL16326 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL2040641 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL16384 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL16419 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL275148 | — | IC50 | = | 710000.0 | nM | - |
| CHEMBL16281 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL16633 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL16365 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL461059 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL277090 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL16444 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL276057 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL16393 | — | IC50 | > | 355000.0 | nM | - |
| CHEMBL16513 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL277286 | — | IC50 | = | 800000.0 | nM | - |
| CHEMBL16295 | — | IC50 | > | 365000.0 | nM | - |