Compound Detail
CHEMBL16384
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Basic Information
| ChEMBL ID | CHEMBL16384 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IDXXPMCEFFCEMO-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
180.1
MW (Da)
-1.28
ALogP
6
HBA
2
HBD
100.9
PSA (Ų)
0.49
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polymerase acidic protein CHEMBL1169598 | IC50 | 4.02 | 4.02 | 95000.0 | 2 |
| unidentified influenza virus CHEMBL613128 | IC50 | 4.02 | 4.02 | 95000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polymerase acidic protein | IC50 | = | 95000.0 | nM | 4.02 | Inhibitory concentration against cap-dependent endonuclease activity of influenz... | 12646026 |
| unidentified influenza virus | IC50 | = | 95000.0 | nM | 4.02 | Antiviral activity against influenza virus | 19112024 |
| Polymerase acidic protein | IC50 | = | 95000.0 | nM | 4.02 | Inhibition of Influenza A/PR/8/34 virus PA endonuclease by cap dependent RNA pol... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12646026 | 10.1021/jm020334u | Polymerase acidic protein | 1 |
| 19112024 | 10.1016/j.bmc.2008.11.075 | unidentified influenza virus | 1 |
| - | 10.1039/C5MD00439J | Polymerase acidic protein | 1 |
Data from ChEMBL 36 via Core Engine