Compound Detail
CHEMBL278402
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Basic Information
| ChEMBL ID | CHEMBL278402 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQORVIRHFMXBSL-STZFKDTASA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
413.9
MW (Da)
4.26
ALogP
4
HBA
2
HBD
77.8
PSA (Ų)
0.40
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polymerase acidic protein CHEMBL1169598 | IC50 | 6.46 | 6.415 | 350.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polymerase acidic protein | IC50 | = | 350.0 | nM | 6.46 | Inhibitory concentration against cap-dependent endonuclease activity of influenz... | 12646026 |
| Polymerase acidic protein | IC50 | = | 430.0 | nM | 6.37 | Inhibitory concentration against cap-dependent endonuclease activity of influenz... | 12646026 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12646026 | 10.1021/jm020334u | Polymerase acidic protein | 2 |
Data from ChEMBL 36 via Core Engine