Assay Detail
Functional
CHEMBL841084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polymerase acidic protein (CHEMBL1169598) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.79 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278402 | — | — | 1 | 6.46 |
| CHEMBL16525 | — | — | 1 | 5.52 |
| CHEMBL278443 | — | — | 1 | 5.10 |
| CHEMBL16239 | — | — | 1 | 5.10 |
| CHEMBL16377 | — | — | 1 | 5.05 |
| CHEMBL16453 | — | — | 1 | 5.02 |
| CHEMBL277536 | — | — | 1 | 5.02 |
| CHEMBL16579 | — | — | 1 | 5.00 |
| CHEMBL16887 | — | — | 1 | 5.00 |
| CHEMBL275631 | — | — | 1 | 5.00 |
| CHEMBL280445 | — | — | 1 | 4.96 |
| CHEMBL429766 | — | — | 1 | 4.85 |
| CHEMBL280446 | — | — | 1 | 4.77 |
| CHEMBL16233 | — | — | 1 | 4.75 |
| CHEMBL16336 | — | — | 1 | 4.70 |
| CHEMBL276316 | — | — | 1 | 4.58 |
| CHEMBL16299 | — | — | 1 | 4.54 |
| CHEMBL1907704 | — | — | 1 | 4.50 |
| CHEMBL279999 | — | — | 1 | 4.46 |
| CHEMBL275420 | — | — | 1 | 4.42 |
| CHEMBL276589 | — | — | 1 | 4.42 |
| CHEMBL16050 | — | — | 1 | 4.40 |
| CHEMBL16313 | — | — | 1 | 4.40 |
| CHEMBL430143 | — | — | 1 | 4.35 |
| CHEMBL16406 | — | — | 1 | 4.32 |
| CHEMBL277284 | — | — | 1 | 4.30 |
| CHEMBL16665 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278402 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL16525 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL278443 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL16239 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL16377 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL16453 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL277536 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL16579 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL16887 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL275631 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL280445 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL429766 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL280446 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL16233 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL16336 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL276316 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL16299 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1907704 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL279999 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL275420 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL276589 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL16050 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL16313 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL430143 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL16406 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL277284 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL16665 | — | IC50 | = | 50000.0 | nM | 4.30 |