Assay Detail
Functional
CHEMBL3108199
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Growth inhibition of human Hs683 cells by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hs 683 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.49 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104836 | — | — | 1 | 4.96 |
| CHEMBL15193 | LAPACHOL | — | 1 | 4.96 |
| CHEMBL376845 | — | — | 1 | 4.75 |
| CHEMBL3104834 | — | — | 1 | 4.55 |
| CHEMBL219541 | — | — | 1 | 4.51 |
| CHEMBL240963 | LAWSONE | — | 1 | 4.51 |
| CHEMBL2023284 | — | — | 1 | 4.48 |
| CHEMBL3104831 | — | — | 1 | 4.44 |
| CHEMBL3104835 | — | — | 1 | 4.39 |
| CHEMBL3104837 | — | — | 1 | 4.38 |
| CHEMBL3104828 | — | — | 1 | 4.32 |
| CHEMBL3104830 | — | — | 1 | 4.07 |
| CHEMBL3104827 | — | — | 1 | 4.05 |
| CHEMBL3104832 | — | — | 1 | - |
| CHEMBL3104829 | — | — | 1 | - |
| CHEMBL3104833 | — | — | 1 | - |
| CHEMBL1317916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104836 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL15193 | LAPACHOL | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL376845 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3104834 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL219541 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL240963 | LAWSONE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2023284 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3104831 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3104835 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3104837 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3104828 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3104830 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL3104827 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL3104832 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3104829 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3104833 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1317916 | — | IC50 | > | 100000.0 | nM | - |