Assay Detail
Functional
CHEMBL3108258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.97 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217270 | — | — | 1 | 9.40 |
| CHEMBL3216850 | — | — | 1 | 9.40 |
| CHEMBL3217053 | — | — | 1 | 9.30 |
| CHEMBL3216167 | — | — | 1 | 8.96 |
| CHEMBL3216615 | — | — | 1 | 8.77 |
| CHEMBL3217052 | — | — | 1 | 8.46 |
| CHEMBL3217049 | — | — | 1 | 8.43 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.40 |
| CHEMBL3215723 | — | — | 1 | 8.39 |
| CHEMBL3105253 | — | — | 1 | 8.32 |
| CHEMBL3215961 | — | — | 1 | 8.30 |
| CHEMBL3217057 | — | — | 1 | 8.15 |
| CHEMBL3216376 | — | — | 1 | 8.13 |
| CHEMBL3217055 | — | — | 1 | 8.02 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 7.85 |
| CHEMBL3105271 | — | — | 1 | 7.82 |
| CHEMBL3217056 | — | — | 1 | 7.78 |
| CHEMBL3215955 | — | — | 1 | 7.75 |
| CHEMBL3216848 | — | — | 1 | 7.72 |
| CHEMBL3217269 | — | — | 1 | 7.66 |
| CHEMBL3217274 | — | — | 1 | 7.60 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.34 |
| CHEMBL3216614 | — | — | 1 | 7.24 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.90 |
| CHEMBL3215722 | — | — | 1 | 6.87 |
| CHEMBL3216170 | — | — | 1 | 6.85 |
| CHEMBL3215956 | — | — | 1 | 6.84 |
| CHEMBL3217058 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217270 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3216850 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3217053 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3216167 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3216615 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3217052 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3217049 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3215723 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3105253 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3215961 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3217057 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3216376 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3217055 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3105271 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3217056 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL3215955 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3216848 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL3217269 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL3217274 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3216614 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3215722 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL3216170 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL3215956 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL3217058 | — | IC50 | = | 327.0 | nM | 6.49 |