Assay Detail
Binding
CHEMBL3108329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.70 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.52 |
| CHEMBL3104851 | — | — | 1 | 5.67 |
| CHEMBL3104855 | — | — | 1 | 5.39 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.27 |
| CHEMBL3104854 | — | — | 1 | 4.63 |
| CHEMBL3104853 | — | — | 1 | - |
| CHEMBL3104852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3104851 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL3104855 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL50 | QUERCETIN | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL3104854 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL3104853 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3104852 | — | IC50 | > | 30000.0 | nM | - |