Assay Detail
Functional
CHEMBL3110992
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Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of plaque formation after 12 hrs by toluidine blue staining assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.15 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.70 |
| CHEMBL3110350 | — | — | 1 | 5.22 |
| CHEMBL3110349 | — | — | 1 | 5.22 |
| CHEMBL3110337 | — | — | 1 | 4.92 |
| CHEMBL3110338 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3110350 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3110349 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3110337 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3110338 | — | EC50 | = | 20000.0 | nM | 4.70 |