Assay Detail
Binding
CHEMBL3111918
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Inhibition of recombinant human factor D expressed in Escherichia coli using Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine as substrate preincubated for 1 hr followed by substrate addition by spectrofluorimetric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of factor d may provide a treatment for age-related macular degeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.48 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3109655 | — | — | 1 | 8.70 |
| CHEMBL3109654 | — | — | 1 | 8.52 |
| CHEMBL3109653 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3109655 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3109654 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3109653 | — | IC50 | = | 6.0 | nM | 8.22 |