Complement factor D · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Complement factor D shows approved-linked disease relevance led by acquired paroxysmal nocturnal hemoglobinuria. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P00746. Start with acquired paroxysmal nocturnal hemoglobinuria, then reuse UniProt P00746 as the stable protein anchor across project notes and exports.
Start with acquired paroxysmal nocturnal hemoglobinuria, then reuse UniProt P00746 as the stable protein anchor across project notes and exports.
Complement factor D shows approved-linked disease relevance led by acquired paroxysmal nocturnal hemoglobinuria. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with acquired paroxysmal nocturnal hemoglobinuria because it currently carries approved-linked support. Linked drugs include DANICOPAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyComplement factor D
Review this target as Complement factor D, mapped to UniProt P00746. Sequence length is 253 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Complement factor D as ChEMBL target CHEMBL2176771, mapped to UniProt P00746. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Complement factor D is the right protein anchor across sources, using UniProt P00746 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acquired paroxysmal nocturnal hemoglobinuria is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Complement factor D |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00746 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Complement factor D |
| UniProt Accession | P00746 |
| Component Type | Protein |
| Sequence Length | 253 aa |
Complement factor D
Review this target as Complement factor D, mapped to UniProt P00746. Sequence length is 253 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Complement factor D shows approved-linked disease relevance led by acquired paroxysmal nocturnal hemoglobinuria. 5 more disease programs remain visible in the same review block.
Start review with acquired paroxysmal nocturnal hemoglobinuria because it currently carries approved-linked support. Linked drugs include DANICOPAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2180765 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4106993 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4114217 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL2180764 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3109655 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL2180766 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3109654 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3668673 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3673724 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3673750 | 8.52 | IC50 | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 46 | 438 | 5.5 |
| assay format | 21 | 1,180 | 6.8 |
| cell-based format | 10 | 136 | 7.0 |
| tissue-based format | 3 | 14 | 6.8 |
| cell-free format | 1 | 1 | 8.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 19 | 6.1 |