Compound Detail
CHEMBL4250860
DANICOPAN 💊 Approved Drug
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💊 Approved Drug
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(-c3cnc(C)nc3)cc12
Basic Information
| ChEMBL ID | CHEMBL4250860 |
| Name | DANICOPAN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | PIBARDGJJAGJAJ-NQIIRXRSSA-N |
| Therapeutic | ✓ Yes |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
4
Known Names
10
Indications
1
Mechanisms
Molecular Properties
580.4
MW (Da)
3.74
ALogP
8
HBA
1
HBD
123.0
PSA (Ų)
0.27
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2024 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Complement factor D inhibitor | INHIBITOR | Complement factor D | ✓ | ✓ |
Indications
Hemoglobinuria, Paroxysmal Hemoglobinuria, Paroxysmal Hemolysis Hemoglobinuria Geographic Atrophy Glomerulonephritis, Membranoproliferative Glomerulonephritis, Membranoproliferative Severe Acute Respiratory Syndrome Kidney Diseases Liver Diseases
ATC Classification
L04AJ09
danicopan
Level 1: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Level 2: IMMUNOSUPPRESSANTS
Activity Summary
IC50 3 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Complement factor D CHEMBL2176771 | IC50 | 8.4 | 8.2067 | 4.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Complement factor D | IC50 | = | 4.0 | nM | 8.4 | Inhibition of factor D in human serum assessed as decrease in alternative pathwa... | 28977749 |
| Complement factor D | IC50 | = | 4.0 | nM | 8.4 | Inhibition of factor D in human serum assessed as decrease in C3 deposition on P... | 28977749 |
| Complement factor D | IC50 | = | 15.0 | nM | 7.82 | Inhibition of human factor D using C3b as substrate assessed as decrease in form... | 28977749 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28977749 | 10.1021/acs.jmedchem.7b00882 | Complement factor D | 5 |
Data from ChEMBL 36 via Core Engine