Assay Detail

CHEMBL4229722

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of factor D in human serum assessed as decrease in C3 deposition on PNH erythrocytes

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Complement factor D (CHEMBL2176771) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Complement factor D (CHEMBL2176771) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Complement factor D

CHEMBL2176771

Anchored from Assay target.

Protein identity Complement factor D

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Complement factor D (CHEMBL2176771) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Chemical Approaches to Modulating Complement-Mediated Diseases.

Iyer A, Xu W, Reid RC, Fairlie DP.
J Med Chem (2018) 61 : 3253 -3276
PubMed 28977749 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC90	1	-	-
IC50	1	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4250860	DANICOPAN	4.0	2	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4250860	DANICOPAN	IC50	=	4.0	nM	8.40
CHEMBL4250860	DANICOPAN	IC90	=	89.0	nM	-