Assay Detail
Functional
CHEMBL3116998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 6.39 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.22 |
| CHEMBL3114032 | — | — | 1 | 7.70 |
| CHEMBL3114037 | — | — | 1 | 7.40 |
| CHEMBL3114041 | — | — | 1 | 7.40 |
| CHEMBL3114049 | — | — | 1 | 7.40 |
| CHEMBL3114054 | — | — | 1 | 7.30 |
| CHEMBL3114034 | — | — | 1 | 7.22 |
| CHEMBL506852 | — | — | 1 | 7.12 |
| CHEMBL3114057 | — | — | 1 | 7.06 |
| CHEMBL3114053 | — | — | 1 | 7.05 |
| CHEMBL3114045 | — | — | 1 | 6.96 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.72 |
| CHEMBL3114051 | — | — | 1 | 6.68 |
| CHEMBL3114050 | — | — | 1 | 6.30 |
| CHEMBL3114047 | — | — | 1 | 6.27 |
| CHEMBL3114033 | — | — | 1 | 6.21 |
| CHEMBL3112604 | — | — | 1 | 5.98 |
| CHEMBL3114055 | — | — | 1 | 5.95 |
| CHEMBL3114059 | — | — | 1 | 5.95 |
| CHEMBL3114052 | — | — | 1 | 5.89 |
| CHEMBL3114038 | — | — | 1 | 5.89 |
| CHEMBL3114039 | — | — | 1 | 5.82 |
| CHEMBL3114042 | — | — | 1 | 5.80 |
| CHEMBL3114058 | — | — | 1 | 5.75 |
| CHEMBL3114035 | — | — | 1 | 5.41 |
| CHEMBL3114046 | — | — | 1 | 5.32 |
| CHEMBL3114043 | — | — | 1 | 5.22 |
| CHEMBL3114056 | — | — | 1 | 4.71 |
| CHEMBL3114060 | — | — | 1 | 4.49 |
| CHEMBL3114036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3114032 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3114037 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3114041 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3114049 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3114054 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3114034 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL506852 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3114057 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3114053 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3114045 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3114051 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3114050 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3114047 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3114033 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3112604 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3114055 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3114059 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3114052 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3114038 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3114039 | — | EC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL3114042 | — | EC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL3114058 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3114035 | — | EC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL3114046 | — | EC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL3114043 | — | EC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL3114056 | — | EC50 | = | 19590.0 | nM | 4.71 |
| CHEMBL3114060 | — | EC50 | = | 32490.0 | nM | 4.49 |
| CHEMBL3114036 | — | EC50 | >= | 25990.0 | nM | - |
| CHEMBL3114040 | — | EC50 | > | 79270.0 | nM | - |
| CHEMBL3114044 | — | EC50 | > | 104830.0 | nM | - |
| CHEMBL3114048 | — | EC50 | > | 88750.0 | nM | - |
| CHEMBL3114031 | — | EC50 | >= | 22570.0 | nM | - |