Assay Detail
Binding
CHEMBL3117477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.72 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3113272 | — | — | 1 | 10.60 |
| CHEMBL3113271 | — | — | 1 | 10.14 |
| CHEMBL3113274 | — | — | 1 | 10.10 |
| CHEMBL3113273 | — | — | 1 | 9.14 |
| CHEMBL3113270 | — | — | 1 | 8.96 |
| CHEMBL3113269 | — | — | 1 | 8.82 |
| CHEMBL3113268 | — | — | 1 | 8.66 |
| CHEMBL3113264 | — | — | 1 | 7.64 |
| CHEMBL3113266 | — | — | 1 | 7.55 |
| CHEMBL3113265 | — | — | 1 | 7.44 |
| CHEMBL3113267 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3113272 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL3113271 | — | IC50 | = | 0.072 | nM | 10.14 |
| CHEMBL3113274 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL3113273 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL3113270 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3113269 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3113268 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3113264 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3113266 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3113265 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3113267 | — | IC50 | = | 140.0 | nM | 6.85 |