Assay Detail
Functional
CHEMBL3117757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453991 | — | — | 1 | 5.70 |
| CHEMBL465183 | DIHOMO-GAMMA-LINOLENIC ACID | 2.0 | 1 | 5.70 |
| CHEMBL460026 | ICOSAPENT | 3.0 | 1 | 5.70 |
| CHEMBL367149 | DOCONEXENT | 3.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453991 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL465183 | DIHOMO-GAMMA-LINOLENIC ACID | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL460026 | ICOSAPENT | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL367149 | DOCONEXENT | IC50 | = | 2000.0 | nM | 5.70 |