Compound Detail
CHEMBL460026
ICOSAPENT 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL460026 |
| Name | ICOSAPENT |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | JAZBEHYOTPTENJ-JLNKQSITSA-N |
11
Targets
13
Activities
4
Assay Types
0
PK Parameters
20
Publications
11
Known Names
20
Indications
1
Mechanisms
Molecular Properties
302.5
MW (Da)
5.99
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.33
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Unknown | - | - | ✓ | ✓ |
Indications
Adenomatous Polyposis Coli Anorexia Arthritis, Rheumatoid Asthma Bipolar Disorder Cachexia Cardiovascular Diseases Cholestasis Coronary Disease Depressive Disorder Depressive Disorder, Major Glomerulonephritis, IGA Heart Failure Hypertriglyceridemia Intestinal Diseases Obesity Psychotic Disorders Psychotic Disorders Severe Acute Respiratory Syndrome Adenoma
Activity Summary
IC50 10 meas. best 6.52
EC50 1 meas. best 4.44
Kd 1 meas. best 5.7
Ki 1 meas. best 5.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Peroxisome proliferator-activated receptor alpha CHEMBL239 | IC50 | 5.96 | 5.96 | 1100.0 | 2 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| Oxoeicosanoid receptor 1 CHEMBL1628461 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | Kd | 5.7 | 5.7 | 2000.0 | 1 |
| Peroxisome proliferator-activated receptor delta CHEMBL3979 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
| Prostaglandin G/H synthase 2 CHEMBL4102 | IC50 | 5.15 | 5.15 | 7100.0 | 1 |
| Retinoic acid receptor RXR-alpha CHEMBL2061 | Ki | 5.12 | 5.12 | 7632.0 | 1 |
| Prostaglandin G/H synthase 1 CHEMBL2860 | IC50 | 4.89 | 4.89 | 13000.0 | 1 |
| Hepatitis C virus CHEMBL379 | EC50 | 4.44 | 4.44 | 36200.0 | 1 |
| Aromatase CHEMBL1978 | IC50 | 4.27 | 4.27 | 53200.0 | 1 |
| Coagulation factor VII/tissue factor CHEMBL2095194 | IC50 | 4.11 | 4.11 | 78000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine