Assay Detail
Binding
CHEMBL958745
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Inhibition of mPGES1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.43 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483894 | — | — | 1 | 9.10 |
| CHEMBL182032 | — | — | 1 | 8.52 |
| CHEMBL180650 | — | — | 1 | 8.52 |
| CHEMBL484092 | — | — | 1 | 7.21 |
| CHEMBL487944 | — | — | 1 | 7.21 |
| CHEMBL453202 | — | — | 1 | 7.21 |
| CHEMBL15594 | ARACHIDONIC ACID | -1.0 | 1 | 6.52 |
| CHEMBL482477 | — | — | 1 | 6.52 |
| CHEMBL460026 | ICOSAPENT | 3.0 | 1 | 6.52 |
| CHEMBL507979 | — | — | 1 | 6.41 |
| CHEMBL486903 | — | — | 1 | 5.96 |
| CHEMBL521286 | — | — | 1 | 5.89 |
| CHEMBL7162 | NS-398 | — | 1 | 4.70 |
| CHEMBL482478 | — | — | 1 | 4.27 |
| CHEMBL519797 | — | — | 1 | 4.19 |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483894 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL182032 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL180650 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL484092 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL487944 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL453202 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL15594 | ARACHIDONIC ACID | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL482477 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL460026 | ICOSAPENT | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL507979 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL486903 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL521286 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL7162 | NS-398 | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL482478 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL519797 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 80000.0 | nM | 4.10 |