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Assay Detail

CHEMBL935038

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Functional
Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type OR6
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.
Yano M, Ikeda M, Abe K, Dansako H, Ohkoshi S, Aoyagi Y, Kato N.
Antimicrob Agents Chemother (2007) 51 : 2016 -2027
PubMed 17420205 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 6 4.81 5.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1536 ERGOCALCIFEROL 4.0 1 5.42
CHEMBL1293 BETA CAROTENE 4.0 1 5.20
CHEMBL267476 LINOLEIC ACID 2.0 1 4.70
CHEMBL15594 ARACHIDONIC ACID -1.0 1 4.66
CHEMBL460026 ICOSAPENT 3.0 1 4.44
CHEMBL367149 DOCONEXENT 3.0 1 4.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1536 ERGOCALCIFEROL EC50 = 3800.0 nM 5.42
CHEMBL1293 BETA CAROTENE EC50 = 6300.0 nM 5.20
CHEMBL267476 LINOLEIC ACID EC50 = 20200.0 nM 4.70
CHEMBL15594 ARACHIDONIC ACID EC50 = 22100.0 nM 4.66
CHEMBL460026 ICOSAPENT EC50 = 36200.0 nM 4.44
CHEMBL367149 DOCONEXENT EC50 = 37000.0 nM 4.43