Assay Detail
Binding
CHEMBL1005509
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Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.59 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.89 |
| CHEMBL460026 | ICOSAPENT | 3.0 | 1 | 4.89 |
| CHEMBL367149 | DOCONEXENT | 3.0 | 1 | 4.82 |
| CHEMBL460444 | — | — | 1 | 4.58 |
| CHEMBL460655 | — | — | 1 | 4.30 |
| CHEMBL541729 | — | — | 1 | 4.09 |
| CHEMBL447250 | — | — | 1 | 4.08 |
| CHEMBL8739 | LINOLENIC ACID | — | 1 | 4.03 |
| CHEMBL267476 | LINOLEIC ACID | 2.0 | 1 | - |
| CHEMBL8659 | OLEIC ACID | 2.0 | 1 | - |
| CHEMBL46403 | STEARIC ACID | -1.0 | 1 | - |
| CHEMBL82293 | PALMITIC ACID | -1.0 | 1 | - |
| CHEMBL460025 | PENTADECANOIC ACID | — | 1 | - |
| CHEMBL111077 | MYRISTIC ACID | -1.0 | 1 | - |
| CHEMBL460445 | — | — | 1 | - |
| CHEMBL460654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL460026 | ICOSAPENT | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL367149 | DOCONEXENT | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL460444 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL460655 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL541729 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL447250 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL8739 | LINOLENIC ACID | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL267476 | LINOLEIC ACID | IC50 | = | 170000.0 | nM | - |
| CHEMBL8659 | OLEIC ACID | IC50 | > | 500000.0 | nM | - |
| CHEMBL46403 | STEARIC ACID | IC50 | > | 500000.0 | nM | - |
| CHEMBL82293 | PALMITIC ACID | IC50 | > | 500000.0 | nM | - |
| CHEMBL460025 | PENTADECANOIC ACID | IC50 | > | 500000.0 | nM | - |
| CHEMBL111077 | MYRISTIC ACID | IC50 | > | 500000.0 | nM | - |
| CHEMBL460445 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL460654 | — | IC50 | > | 500000.0 | nM | - |