Assay Detail
Functional
CHEMBL3118048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,2,3-triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.56 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL3114589 | — | — | 1 | 6.48 |
| CHEMBL3114588 | — | — | 1 | 6.27 |
| CHEMBL2375476 | — | — | 1 | 5.50 |
| CHEMBL3114423 | — | — | 1 | 5.48 |
| CHEMBL3114580 | — | — | 1 | 5.36 |
| CHEMBL2375474 | — | — | 1 | 5.31 |
| CHEMBL2375478 | — | — | 1 | 5.31 |
| CHEMBL2375552 | — | — | 1 | 5.26 |
| CHEMBL3114585 | — | — | 1 | 5.25 |
| CHEMBL3114586 | — | — | 1 | 5.23 |
| CHEMBL3114583 | — | — | 1 | 5.18 |
| CHEMBL2375477 | — | — | 1 | 5.08 |
| CHEMBL3114420 | — | — | 1 | 5.07 |
| CHEMBL2375473 | — | — | 1 | 4.98 |
| CHEMBL2441125 | — | — | 1 | - |
| CHEMBL2441124 | — | — | 1 | - |
| CHEMBL2441123 | — | — | 1 | - |
| CHEMBL2441122 | — | — | 1 | - |
| CHEMBL3114424 | — | — | 1 | - |
| CHEMBL2441121 | — | — | 1 | - |
| CHEMBL2441120 | — | — | 1 | - |
| CHEMBL2441119 | — | — | 1 | - |
| CHEMBL2441118 | — | — | 1 | - |
| CHEMBL2441117 | — | — | 1 | - |
| CHEMBL2441116 | — | — | 1 | - |
| CHEMBL2441115 | — | — | 1 | - |
| CHEMBL3114421 | — | — | 1 | - |
| CHEMBL3114587 | — | — | 1 | - |
| CHEMBL3114422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3114589 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3114588 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2375476 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3114423 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3114580 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL2375474 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL2375478 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL2375552 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL3114585 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL3114586 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL3114583 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL2375477 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL3114420 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL2375473 | — | IC50 | = | 10470.0 | nM | 4.98 |
| CHEMBL3114584 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114582 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3114581 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL3114419 | — | IC50 | - | — | - | |
| CHEMBL2441126 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL2441125 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL2441124 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL2441123 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL2441122 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441121 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441120 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441119 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL2441118 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441117 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL2441116 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL2441115 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3114421 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3114587 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114422 | — | IC50 | > | 14000.0 | nM | - |