Assay Detail
Functional
CHEMBL3118185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 assessed as parasite growth inhibition after 70 hrs by Alamar blue assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Activity of diimidazoline amides against African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.23 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361506 | PENTAMIDINE ISETHIONATE | 4.0 | 1 | 8.82 |
| CHEMBL3113731 | — | — | 1 | 8.82 |
| CHEMBL3113730 | — | — | 1 | 8.66 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.42 |
| CHEMBL3113720 | — | — | 1 | 8.33 |
| CHEMBL3113724 | — | — | 1 | 7.96 |
| CHEMBL3113727 | — | — | 1 | 7.72 |
| CHEMBL3113732 | — | — | 1 | 7.64 |
| CHEMBL3113721 | — | — | 1 | 7.29 |
| CHEMBL3113729 | — | — | 1 | 7.07 |
| CHEMBL3113726 | — | — | 1 | 6.92 |
| CHEMBL3113725 | — | — | 1 | 6.92 |
| CHEMBL3113728 | — | — | 1 | 6.16 |
| CHEMBL3113733 | — | — | 1 | 5.66 |
| CHEMBL3113722 | — | — | 1 | 5.02 |
| CHEMBL3113723 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361506 | PENTAMIDINE ISETHIONATE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3113731 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3113730 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3113720 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3113724 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3113727 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3113732 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3113721 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3113729 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3113726 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3113725 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3113728 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3113733 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3113722 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3113723 | — | IC50 | = | 64000.0 | nM | 4.19 |