Assay Detail
Binding
CHEMBL3118965
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Inhibition of HIV wild-type reverse transcriptase by electrochemiluminescence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.07 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.00 |
| CHEMBL3115364 | — | — | 1 | 9.00 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 9.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL3115366 | — | — | 1 | 8.70 |
| CHEMBL1928645 | — | — | 1 | 8.52 |
| CHEMBL3115363 | — | — | 1 | 8.52 |
| CHEMBL3115352 | — | — | 1 | 8.52 |
| CHEMBL3115353 | — | — | 1 | 8.40 |
| CHEMBL3115355 | — | — | 1 | 8.30 |
| CHEMBL3115367 | — | — | 1 | 8.30 |
| CHEMBL3115365 | — | — | 1 | 8.22 |
| CHEMBL3115354 | — | — | 1 | 8.22 |
| CHEMBL1928643 | — | — | 1 | 8.15 |
| CHEMBL3115351 | — | — | 1 | 8.15 |
| CHEMBL3115349 | — | — | 1 | 8.15 |
| CHEMBL3115348 | — | — | 1 | 8.15 |
| CHEMBL3115350 | — | — | 1 | 8.15 |
| CHEMBL3115368 | — | — | 1 | 8.05 |
| CHEMBL3115358 | — | — | 1 | 7.96 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 7.96 |
| CHEMBL3115356 | — | — | 1 | 7.80 |
| CHEMBL3115347 | — | — | 1 | 7.68 |
| CHEMBL3115361 | — | — | 1 | 7.37 |
| CHEMBL3115362 | — | — | 1 | 7.30 |
| CHEMBL3115359 | — | — | 1 | 6.85 |
| CHEMBL3115360 | — | — | 1 | 6.52 |
| CHEMBL3115357 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3115364 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3115366 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1928645 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3115363 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3115352 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3115353 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3115355 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3115367 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3115365 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3115354 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1928643 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3115351 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3115349 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3115348 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3115350 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3115368 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3115358 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2364608 | DORAVIRINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3115356 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3115347 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3115361 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3115362 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3115359 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3115360 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3115357 | — | IC50 | = | 390.0 | nM | 6.41 |