Assay Detail
Binding
CHEMBL3118992
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Inhibition of JAK3 (unknown origin)
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.82 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650951 | — | — | 1 | 9.30 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.85 |
| CHEMBL3114786 | — | — | 1 | 7.92 |
| CHEMBL3114761 | — | — | 1 | 7.89 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 7.84 |
| CHEMBL366266 | — | — | 1 | 7.77 |
| CHEMBL3114774 | — | — | 1 | 7.54 |
| CHEMBL3114776 | — | — | 1 | 7.34 |
| CHEMBL3114766 | — | — | 1 | 6.89 |
| CHEMBL3114771 | — | — | 1 | 6.87 |
| CHEMBL3114784 | — | — | 1 | 6.79 |
| CHEMBL3114775 | — | — | 1 | 6.75 |
| CHEMBL3114785 | — | — | 1 | 6.70 |
| CHEMBL3114772 | — | — | 1 | 6.70 |
| CHEMBL3114768 | — | — | 1 | 6.56 |
| CHEMBL3114778 | — | — | 1 | 6.39 |
| CHEMBL3114762 | — | — | 1 | 6.30 |
| CHEMBL3114781 | — | — | 1 | 6.24 |
| CHEMBL3114765 | — | — | 1 | 6.24 |
| CHEMBL3114783 | — | — | 1 | 6.20 |
| CHEMBL3114769 | — | — | 1 | 5.94 |
| CHEMBL3114779 | — | — | 1 | 5.86 |
| CHEMBL3114780 | — | — | 1 | 5.86 |
| CHEMBL3114777 | — | — | 1 | 5.82 |
| CHEMBL3114767 | — | — | 1 | 5.75 |
| CHEMBL3114770 | — | — | 1 | 5.03 |
| CHEMBL3114763 | — | — | 1 | - |
| CHEMBL3114764 | — | — | 1 | - |
| CHEMBL3114773 | — | — | 1 | - |
| CHEMBL3114782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650951 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3114786 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3114761 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL366266 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3114774 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3114776 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3114766 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL3114771 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3114784 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL3114775 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL3114785 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3114772 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL3114768 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL3114778 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL3114762 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL3114781 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL3114765 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL3114783 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL3114769 | — | IC50 | = | 1148.0 | nM | 5.94 |
| CHEMBL3114779 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3114780 | — | IC50 | = | 1387.0 | nM | 5.86 |
| CHEMBL3114777 | — | IC50 | = | 1499.0 | nM | 5.82 |
| CHEMBL3114767 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL3114770 | — | IC50 | = | 9367.0 | nM | 5.03 |
| CHEMBL3114763 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114764 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114773 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114782 | — | IC50 | > | 10000.0 | nM | - |