Assay Detail
Binding
CHEMBL3119218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of demethylase activity of PCA-1 (unknown origin) using 3-methyl cytosine oligo DNA as substrate after 1 hr by RT-PCR analysis
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (CHEMBL3112376) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.80 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3145429 | — | — | 1 | 6.32 |
| CHEMBL3145446 | — | — | 1 | 6.31 |
| CHEMBL3145436 | — | — | 1 | 6.27 |
| CHEMBL3145440 | — | — | 1 | 6.26 |
| CHEMBL3145451 | — | — | 1 | 6.24 |
| CHEMBL3145441 | — | — | 1 | 6.22 |
| CHEMBL3145447 | — | — | 1 | 6.21 |
| CHEMBL3145442 | — | — | 1 | 6.20 |
| CHEMBL3145448 | — | — | 1 | 6.19 |
| CHEMBL3145419 | — | — | 1 | 6.17 |
| CHEMBL3145452 | — | — | 1 | 6.17 |
| CHEMBL3145443 | — | — | 1 | 6.14 |
| CHEMBL3145410 | — | — | 1 | 6.14 |
| CHEMBL3145430 | — | — | 1 | 6.12 |
| CHEMBL3145412 | — | — | 1 | 6.12 |
| CHEMBL3145413 | — | — | 1 | 6.11 |
| CHEMBL3145449 | — | — | 1 | 6.09 |
| CHEMBL3145411 | — | — | 1 | 6.04 |
| CHEMBL3145408 | — | — | 1 | 5.82 |
| CHEMBL3145246 | — | — | 1 | 5.77 |
| CHEMBL3114990 | — | — | 1 | 5.70 |
| CHEMBL3145409 | — | — | 1 | 5.68 |
| CHEMBL3145427 | — | — | 1 | 5.58 |
| CHEMBL3145439 | — | — | 1 | 5.51 |
| CHEMBL3145435 | — | — | 1 | 5.48 |
| CHEMBL3145417 | — | — | 1 | 5.44 |
| CHEMBL3145414 | — | — | 1 | 5.43 |
| CHEMBL3145421 | — | — | 1 | 5.40 |
| CHEMBL3145444 | — | — | 1 | 5.39 |
| CHEMBL3145431 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3145429 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3145446 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3145436 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3145440 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3145451 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3145441 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3145447 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3145442 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3145448 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3145419 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3145452 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3145443 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3145410 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3145430 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3145412 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3145413 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3145449 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3145411 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3145408 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3145246 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3114990 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3145409 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3145427 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3145439 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3145435 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3145417 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3145414 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3145421 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3145444 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3145431 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3145445 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3145415 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3114991 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3145450 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3145067 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3145432 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3145416 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145422 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145425 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145426 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145428 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145434 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145418 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145437 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3145438 | — | IC50 | > | 10000.0 | nM | - |