Assay Detail
Binding
CHEMBL3119262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human coagulation factor 10a using S-2765 as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.92 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3115900 | — | — | 1 | 5.10 |
| CHEMBL3115903 | — | — | 1 | 4.85 |
| CHEMBL215295 | — | — | 1 | 4.80 |
| CHEMBL3115901 | — | — | 1 | - |
| CHEMBL3115894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3115900 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL3115903 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL215295 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL3115901 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL3115894 | — | Ki | > | 43000.0 | nM | - |