Assay Detail
Binding
CHEMBL3119481
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Inhibition of Escherichia coli GroEL/GroES-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 2 hrs by fluorescence based assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A biochemical screen for GroEL/GroES inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.75 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3115908 | — | — | 1 | 7.22 |
| CHEMBL3115911 | — | — | 1 | 5.48 |
| CHEMBL2146958 | — | — | 1 | 5.01 |
| CHEMBL1632145 | — | — | 1 | 4.89 |
| CHEMBL3112623 | — | — | 1 | 4.64 |
| CHEMBL3115909 | — | — | 1 | 4.60 |
| CHEMBL1376711 | — | — | 1 | 4.60 |
| CHEMBL3115915 | — | — | 1 | 4.36 |
| CHEMBL3115918 | — | — | 1 | 4.32 |
| CHEMBL3116086 | — | — | 1 | 4.28 |
| CHEMBL3115916 | — | — | 1 | 4.17 |
| CHEMBL3115914 | — | — | 1 | 4.15 |
| CHEMBL3115922 | — | — | 1 | 4.02 |
| CHEMBL3115927 | — | — | 1 | - |
| CHEMBL3115926 | — | — | 1 | - |
| CHEMBL3115925 | — | — | 1 | - |
| CHEMBL1411862 | — | — | 1 | - |
| CHEMBL3115924 | — | — | 1 | - |
| CHEMBL1557710 | — | — | 1 | - |
| CHEMBL3115923 | — | — | 1 | - |
| CHEMBL3115921 | — | — | 1 | - |
| CHEMBL3115920 | — | — | 1 | - |
| CHEMBL3116090 | — | — | 1 | - |
| CHEMBL3115919 | — | — | 1 | - |
| CHEMBL3115917 | — | — | 1 | - |
| CHEMBL214344 | — | — | 1 | - |
| CHEMBL1713063 | — | — | 1 | - |
| CHEMBL3115913 | — | — | 1 | - |
| CHEMBL3115912 | — | — | 1 | - |
| CHEMBL3115910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3115908 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3115911 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2146958 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1632145 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3112623 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3115909 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1376711 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3115915 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL3115918 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3116086 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL3115916 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3115914 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL3115922 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL3116089 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3116088 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3116087 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115929 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1775067 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL3115928 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115927 | — | IC50 | = | 236000.0 | nM | - |
| CHEMBL3115926 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115925 | — | IC50 | = | 217000.0 | nM | - |
| CHEMBL1411862 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115924 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL1557710 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115923 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115921 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115920 | — | IC50 | = | 131000.0 | nM | - |
| CHEMBL3116090 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115919 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115917 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL214344 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1713063 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115913 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115912 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3115910 | — | IC50 | = | 150000.0 | nM | - |