Assay Detail
Functional
CHEMBL3119804
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Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SGC-7901 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel coumarin-dihydropyrazole thio-ethanone derivatives: design, synthesis and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.10 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3115522 | — | — | 1 | 5.64 |
| CHEMBL3115514 | — | — | 1 | 5.54 |
| CHEMBL3115524 | — | — | 1 | 5.48 |
| CHEMBL3115518 | — | — | 1 | 5.36 |
| CHEMBL3115509 | — | — | 1 | 5.36 |
| CHEMBL3115513 | — | — | 1 | 5.30 |
| CHEMBL3115519 | — | — | 1 | 5.14 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.13 |
| CHEMBL3115521 | — | — | 1 | 5.09 |
| CHEMBL3115517 | — | — | 1 | 5.07 |
| CHEMBL3115515 | — | — | 1 | 5.01 |
| CHEMBL3115512 | — | — | 1 | 5.01 |
| CHEMBL3115525 | — | — | 1 | 4.99 |
| CHEMBL3115510 | — | — | 1 | 4.99 |
| CHEMBL3115516 | — | — | 1 | 4.92 |
| CHEMBL3115523 | — | — | 1 | 4.91 |
| CHEMBL3115520 | — | — | 1 | 4.84 |
| CHEMBL3115511 | — | — | 1 | 4.83 |
| CHEMBL3112619 | — | — | 1 | 4.69 |
| CHEMBL3115526 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3115522 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3115514 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL3115524 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3115518 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL3115509 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL3115513 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL3115519 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL3115521 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL3115517 | — | IC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL3115515 | — | IC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL3115512 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL3115525 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3115510 | — | IC50 | = | 10250.0 | nM | 4.99 |
| CHEMBL3115516 | — | IC50 | = | 12070.0 | nM | 4.92 |
| CHEMBL3115523 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL3115520 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3115511 | — | IC50 | = | 14660.0 | nM | 4.83 |
| CHEMBL3112619 | — | IC50 | = | 20310.0 | nM | 4.69 |
| CHEMBL3115526 | — | IC50 | = | 24140.0 | nM | 4.62 |