Assay Detail
Functional
CHEMBL3122500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human CCD-39SK cells assessed as inhibition of IL-1beta-induced IL-6 production incubated for 60 mins prior to IL-1beta induction measured after 24 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCD-39SK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.99 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120317 | — | — | 1 | 8.36 |
| CHEMBL3120318 | — | — | 1 | 8.32 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.14 |
| CHEMBL3120319 | — | — | 1 | 8.03 |
| CHEMBL3120320 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120317 | — | IC50 | = | 4.38 | nM | 8.36 |
| CHEMBL3120318 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL131 | PREDNISOLONE | IC50 | = | 7.26 | nM | 8.14 |
| CHEMBL3120319 | — | IC50 | = | 9.32 | nM | 8.03 |
| CHEMBL3120320 | — | IC50 | = | 75.9 | nM | 7.12 |