Assay Detail

CHEMBL3124134

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Binding

Antagonist activity at rat spleen CB2 receptor

ChEMBL ↗

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Target

Cannabinoid receptor 2 (CHEMBL2470) ↗

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Cannabinoid receptor 2 (CHEMBL2470) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cannabinoid receptor 2

CHEMBL2470

Anchored from Assay target.

Protein identity Cannabinoid receptor 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Tissue	Spleen
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cannabinoid receptor 2 (CHEMBL2470) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists.

Han S, Zhang FF, Xie X, Chen JZ.
Eur J Med Chem (2014) 74 : 73 -84
PubMed 24445310 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.22	9.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL381689	SR-144528	—	1	9.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL381689	SR-144528	Ki	=	0.6	nM	9.22