Assay Detail
Functional
CHEMBL3124147
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Cytotoxicity against human ColoR cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ColoR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzofuran derivatives as a novel class of inhibitors of mTOR signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.12 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120229 | — | — | 1 | 5.43 |
| CHEMBL3120215 | OSI-027 | 2.0 | 1 | 5.24 |
| CHEMBL1908360 | EVEROLIMUS | 4.0 | 1 | 5.06 |
| CHEMBL3120214 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120229 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3120215 | OSI-027 | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1908360 | EVEROLIMUS | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3120214 | — | IC50 | = | 18000.0 | nM | 4.75 |