Assay Detail
Binding
CHEMBL3124255
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Inhibition of bovine xanthine oxidase using xanthine as substrate measured for 6 mins at 25 degC by spectrophotometry
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.14 | 5.55 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2338661 | — | — | 2 | 5.55 |
| CHEMBL3121613 | — | — | 1 | 5.41 |
| CHEMBL2338666 | — | — | 1 | 5.07 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 4.95 |
| CHEMBL2338671 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2338661 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL3121613 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL2338666 | — | IC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL2338671 | — | IC50 | = | 18670.0 | nM | 4.73 |
| CHEMBL2338661 | — | Inhibition | - | % | - |