Assay Detail
Binding
CHEMBL3124369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of iNOS in mouse RAW264.7 cells assessed as LPS-induced nitric oxide production treated for 30 mins followed by LPS challenge measured after 24 hrs by Griess reagent method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against inflammation and metabolic disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.98 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298697 | — | — | 1 | 5.98 |
| CHEMBL3120612 | — | — | 1 | - |
| CHEMBL3120613 | — | — | 1 | - |
| CHEMBL3120614 | — | — | 1 | - |
| CHEMBL3120615 | — | — | 1 | - |
| CHEMBL3120616 | — | — | 1 | - |
| CHEMBL3120617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298697 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3120612 | — | IC50 | - | — | - | |
| CHEMBL3120613 | — | IC50 | - | — | - | |
| CHEMBL3120614 | — | IC50 | - | — | - | |
| CHEMBL3120615 | — | IC50 | - | — | - | |
| CHEMBL3120616 | — | IC50 | - | — | - | |
| CHEMBL3120617 | — | IC50 | - | — | - |