Assay Detail
Binding
CHEMBL3128334
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Displacement of [3H]WIN35,428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting analysis
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 5.81 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3126735 | — | — | 1 | 6.94 |
| CHEMBL1516187 | — | — | 1 | 6.85 |
| CHEMBL3126717 | — | — | 1 | 6.74 |
| CHEMBL3126747 | — | — | 1 | 6.65 |
| CHEMBL3126720 | — | — | 1 | 6.62 |
| CHEMBL3126749 | — | — | 1 | 6.56 |
| CHEMBL3126730 | — | — | 1 | 6.53 |
| CHEMBL3126734 | — | — | 1 | 6.53 |
| CHEMBL3126733 | — | — | 1 | 6.51 |
| CHEMBL3126722 | — | — | 1 | 6.39 |
| CHEMBL3126732 | — | — | 1 | 6.36 |
| CHEMBL3126746 | — | — | 1 | 6.36 |
| CHEMBL3126731 | — | — | 1 | 6.32 |
| CHEMBL3126727 | — | — | 1 | 6.26 |
| CHEMBL3126738 | — | — | 1 | 6.23 |
| CHEMBL3126736 | — | — | 1 | 6.21 |
| CHEMBL3126718 | — | — | 1 | 6.19 |
| CHEMBL3126744 | — | — | 1 | 6.14 |
| CHEMBL3126726 | — | — | 1 | 6.05 |
| CHEMBL3126741 | — | — | 1 | 6.01 |
| CHEMBL3126737 | — | — | 1 | 5.96 |
| CHEMBL3126721 | — | — | 1 | 5.94 |
| CHEMBL3126756 | — | — | 1 | 5.91 |
| CHEMBL3126719 | — | — | 1 | 5.90 |
| CHEMBL3126729 | — | — | 1 | 5.89 |
| CHEMBL3126716 | — | — | 1 | 5.80 |
| CHEMBL3126745 | — | — | 1 | 5.70 |
| CHEMBL1373 | MODAFINIL | 4.0 | 1 | 5.58 |
| CHEMBL3126752 | — | — | 1 | 5.52 |
| CHEMBL3126751 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3126735 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL1516187 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL3126717 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL3126747 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL3126720 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL3126749 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL3126730 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL3126734 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL3126733 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3126722 | — | Ki | = | 405.0 | nM | 6.39 |
| CHEMBL3126732 | — | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL3126746 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL3126731 | — | Ki | = | 483.0 | nM | 6.32 |
| CHEMBL3126727 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL3126738 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL3126736 | — | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL3126718 | — | Ki | = | 645.0 | nM | 6.19 |
| CHEMBL3126744 | — | Ki | = | 722.0 | nM | 6.14 |
| CHEMBL3126726 | — | Ki | = | 881.0 | nM | 6.05 |
| CHEMBL3126741 | — | Ki | = | 975.0 | nM | 6.01 |
| CHEMBL3126737 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL3126721 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL3126756 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL3126719 | — | Ki | = | 1270.0 | nM | 5.90 |
| CHEMBL3126729 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL3126716 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL3126745 | — | Ki | = | 2020.0 | nM | 5.70 |
| CHEMBL1373 | MODAFINIL | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3126752 | — | Ki | = | 3010.0 | nM | 5.52 |
| CHEMBL3126751 | — | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL3126725 | — | Ki | = | 5930.0 | nM | 5.23 |
| CHEMBL3126743 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL3126740 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL3126753 | — | Ki | = | 8370.0 | nM | 5.08 |
| CHEMBL3126755 | — | Ki | = | 11700.0 | nM | 4.93 |
| CHEMBL3126748 | — | Ki | = | 12400.0 | nM | 4.91 |
| CHEMBL3126723 | — | Ki | = | 12700.0 | nM | 4.90 |
| CHEMBL3126728 | — | Ki | = | 13100.0 | nM | 4.88 |
| CHEMBL3126739 | — | Ki | = | 13600.0 | nM | 4.87 |
| CHEMBL3126750 | — | Ki | = | 19300.0 | nM | 4.71 |
| CHEMBL3126754 | — | Ki | = | 20700.0 | nM | 4.68 |
| CHEMBL3126742 | — | Ki | = | 23600.0 | nM | 4.63 |
| CHEMBL3126724 | — | Ki | = | 35400.0 | nM | 4.45 |