Assay Detail
Functional
CHEMBL3129229
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Antiproliferative activity against human HeLaS3 cells after 72 hrs by XTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa S3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 5.75 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269812 | — | — | 1 | 7.70 |
| CHEMBL1814768 | — | — | 1 | 7.70 |
| CHEMBL1814767 | — | — | 1 | 7.30 |
| CHEMBL3127055 | — | — | 1 | 6.96 |
| CHEMBL3126907 | — | — | 1 | 6.72 |
| CHEMBL3127057 | — | — | 1 | 6.60 |
| CHEMBL3127049 | — | — | 1 | 6.27 |
| CHEMBL3126905 | — | — | 1 | 6.09 |
| CHEMBL3127065 | — | — | 1 | 5.99 |
| CHEMBL3126899 | — | — | 1 | 5.92 |
| CHEMBL3126908 | — | — | 1 | 5.88 |
| CHEMBL3127047 | — | — | 1 | 5.76 |
| CHEMBL3127066 | — | — | 1 | 5.75 |
| CHEMBL3127067 | — | — | 1 | 5.75 |
| CHEMBL3127054 | — | — | 1 | 5.71 |
| CHEMBL3127051 | — | — | 1 | 5.71 |
| CHEMBL3127068 | — | — | 1 | 5.47 |
| CHEMBL3126915 | — | — | 1 | 5.39 |
| CHEMBL3126865 | — | — | 1 | 5.38 |
| CHEMBL3127058 | — | — | 1 | 5.30 |
| CHEMBL3127050 | — | — | 1 | 5.27 |
| CHEMBL3126879 | — | — | 1 | 5.24 |
| CHEMBL3126900 | — | — | 1 | 5.04 |
| CHEMBL3127046 | — | — | 1 | 5.03 |
| CHEMBL3126906 | — | — | 1 | 4.97 |
| CHEMBL3126874 | — | — | 1 | 4.97 |
| CHEMBL3127056 | — | — | 1 | 4.92 |
| CHEMBL3127044 | — | — | 1 | 4.86 |
| CHEMBL3126911 | — | — | 1 | 4.84 |
| CHEMBL3127048 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269812 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1814768 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1814767 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3127055 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3126907 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3127057 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3127049 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3126905 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3127065 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3126899 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3126908 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL3127047 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL3127067 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3127066 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL3127051 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3127054 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL3127068 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL3126915 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL3126865 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL3127058 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3127050 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL3126879 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL3126900 | — | IC50 | = | 9060.0 | nM | 5.04 |
| CHEMBL3127046 | — | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL3126874 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3126906 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3127056 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL3127044 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3126911 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3127048 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3126914 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL3127059 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127060 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127061 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127063 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126898 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL319177 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126909 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126912 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126913 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126880 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3124960 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126881 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126882 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126883 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127064 | — | IC50 | > | 20000.0 | nM | - |