Assay Detail
ADMET
CHEMBL3129233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytostatic activity against human BJ cells after 72 hrs by MTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | BJ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 4.70 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3126914 | — | — | 1 | 7.30 |
| CHEMBL3126908 | — | — | 1 | 7.16 |
| CHEMBL1269812 | — | — | 1 | 7.16 |
| CHEMBL3127049 | — | — | 1 | 6.58 |
| CHEMBL3126905 | — | — | 1 | 6.39 |
| CHEMBL3127065 | — | — | 1 | 6.37 |
| CHEMBL3127058 | — | — | 1 | 5.30 |
| CHEMBL3126906 | — | — | 1 | 5.28 |
| CHEMBL1814767 | — | — | 1 | 4.74 |
| CHEMBL3126874 | — | — | 1 | 4.67 |
| CHEMBL3127046 | — | — | 1 | 4.65 |
| CHEMBL3126865 | — | — | 1 | 4.61 |
| CHEMBL3126871 | — | — | 1 | 4.59 |
| CHEMBL3127066 | — | — | 1 | 4.54 |
| CHEMBL3126907 | — | — | 1 | 4.34 |
| CHEMBL3126883 | — | — | 1 | 4.20 |
| CHEMBL3127067 | — | — | 1 | 4.20 |
| CHEMBL3127068 | — | — | 1 | 4.19 |
| CHEMBL1814768 | — | — | 1 | 4.18 |
| CHEMBL3127054 | — | — | 1 | 4.17 |
| CHEMBL3127055 | — | — | 1 | 4.16 |
| CHEMBL3127063 | — | — | 1 | 4.12 |
| CHEMBL3127064 | — | — | 1 | 4.07 |
| CHEMBL3127057 | — | — | 1 | 4.07 |
| CHEMBL3126909 | — | — | 1 | 4.05 |
| CHEMBL3127048 | — | — | 1 | 4.04 |
| CHEMBL3126898 | — | — | 1 | 4.04 |
| CHEMBL3126913 | — | — | 1 | 4.03 |
| CHEMBL3127052 | — | — | 1 | 4.02 |
| CHEMBL3127059 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3126914 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3126908 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1269812 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3127049 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3126905 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3127065 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3127058 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL3126906 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1814767 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3126874 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3127046 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL3126865 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL3126871 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL3127066 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL3126907 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL3126883 | — | IC50 | = | 62700.0 | nM | 4.20 |
| CHEMBL3127067 | — | IC50 | = | 62800.0 | nM | 4.20 |
| CHEMBL3127068 | — | IC50 | = | 64300.0 | nM | 4.19 |
| CHEMBL1814768 | — | IC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL3127054 | — | IC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL3127055 | — | IC50 | = | 68600.0 | nM | 4.16 |
| CHEMBL3127063 | — | IC50 | = | 75600.0 | nM | 4.12 |
| CHEMBL3127064 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL3127057 | — | IC50 | = | 86100.0 | nM | 4.07 |
| CHEMBL3126909 | — | IC50 | = | 89200.0 | nM | 4.05 |
| CHEMBL3127048 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL3126898 | — | IC50 | = | 91400.0 | nM | 4.04 |
| CHEMBL3126913 | — | IC50 | = | 93900.0 | nM | 4.03 |
| CHEMBL3127052 | — | IC50 | = | 95800.0 | nM | 4.02 |
| CHEMBL3127059 | — | IC50 | = | 96300.0 | nM | 4.02 |
| CHEMBL3127051 | — | IC50 | = | 96900.0 | nM | 4.01 |
| CHEMBL3126911 | — | IC50 | = | 96900.0 | nM | 4.01 |
| CHEMBL3127047 | — | IC50 | = | 98400.0 | nM | 4.01 |
| CHEMBL3126868 | — | IC50 | = | 99900.0 | nM | 4.00 |
| CHEMBL3127050 | — | IC50 | = | 98800.0 | nM | 4.00 |
| CHEMBL3126900 | — | IC50 | = | 99200.0 | nM | 4.00 |
| CHEMBL3126901 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126902 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126912 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126915 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127044 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126879 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126880 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3124960 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126881 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126882 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126884 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 100000.0 | nM | - |