Assay Detail
Functional
CHEMBL3129234
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Cytostatic activity against p53-deficient human HCT116 cells after 72 hrs by MTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 6.06 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3127049 | — | — | 1 | 8.00 |
| CHEMBL3127065 | — | — | 1 | 7.40 |
| CHEMBL3126908 | — | — | 1 | 7.40 |
| CHEMBL1814768 | — | — | 1 | 7.22 |
| CHEMBL1269812 | — | — | 1 | 7.22 |
| CHEMBL3127055 | — | — | 1 | 7.05 |
| CHEMBL3127050 | — | — | 1 | 7.00 |
| CHEMBL3126907 | — | — | 1 | 6.92 |
| CHEMBL3127066 | — | — | 1 | 6.89 |
| CHEMBL3127068 | — | — | 1 | 6.85 |
| CHEMBL1814767 | — | — | 1 | 6.77 |
| CHEMBL3126905 | — | — | 1 | 6.54 |
| CHEMBL3126899 | — | — | 1 | 6.50 |
| CHEMBL3127067 | — | — | 1 | 6.36 |
| CHEMBL3127058 | — | — | 1 | 6.36 |
| CHEMBL3126911 | — | — | 1 | 5.84 |
| CHEMBL3126906 | — | — | 1 | 5.29 |
| CHEMBL3127047 | — | — | 1 | 5.29 |
| CHEMBL3126915 | — | — | 1 | 5.12 |
| CHEMBL3126895 | — | — | 1 | 4.88 |
| CHEMBL3126889 | — | — | 1 | 4.85 |
| CHEMBL3127046 | — | — | 1 | 4.84 |
| CHEMBL3126880 | — | — | 1 | 4.83 |
| CHEMBL3126874 | — | — | 1 | 4.75 |
| CHEMBL3127044 | — | — | 1 | 4.71 |
| CHEMBL3126875 | — | — | 1 | 4.70 |
| CHEMBL3126912 | — | — | 1 | 4.02 |
| CHEMBL3127060 | — | — | 1 | - |
| CHEMBL3126914 | — | — | 1 | - |
| CHEMBL3126913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3127049 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3127065 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3126908 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1814768 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1269812 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3127055 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3127050 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3126907 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3127066 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3127068 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1814767 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3126905 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3126899 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3127058 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3127067 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3126911 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL3126906 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL3127047 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL3126915 | — | IC50 | = | 7570.0 | nM | 5.12 |
| CHEMBL3126895 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL3126889 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3127046 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3126880 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3126874 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL3127044 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL3126875 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3126912 | — | IC50 | = | 95300.0 | nM | 4.02 |
| CHEMBL3127064 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127048 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127051 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127052 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127053 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127054 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127056 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127057 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127059 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127062 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127061 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127063 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126898 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126900 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126902 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126909 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126910 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126913 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126914 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127060 | — | IC50 | > | 20000.0 | nM | - |